What is it about?
The aim of this study is to develop naturally mimicking flavonoid scaffolds by synthetic approach. The synthesised flavone and flavanone cores were characterised by various spectroscopic methods. The molecular modelling of synthesised compounds were observed for physicochemical properties, ADMET and molecular simulation on cyclooxygenase-2. The pharmacological evaluation of synthesised compounds by in-vitro methods and in-vivo methods on acute and chronic models were observed for anti-inflammatory activity. The synthesised hybrids with electron donating groups (methoxy, hydroxy and some heterocyclic rings )were produced significant result and well correlated the hypothesis of this research.
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Why is it important?
Drug discovery is an important aspect to develop the potent drug for the treatment of inflammatory responses in major chronic diseases. The existing few NSAID's were promoted adverse effects on long term therapy for the management of certain diseases like rheumatoid arthritis, cancer, diabetes and neurodegenerative disorders. Hence designing the drug molecules in the natural way definitely paves the way for the futuristic drug discovery as potential anti-inflammatory agents.
Perspectives
I feel great pleasure by writing this article as an corresponding author, this is my part of Ph.D dissertation. The synthesis of flavonoid scaffolds were quite challenging in this study, followed by characterisation should be very important for this research. Taking these naturally mimicking synthesised flavanoids to reach the rural people with cheaper of cost as well effective in the management of chronic infectious diseases as an potent anti-inflammatory agent.
Kiruthiga Natarajan
Nandha college of Pharmacy
Read the Original
This page is a summary of: Molecular modelling, Synthesis and Evaluation of Flavone and Flavanone Scaffolds as Anti-inflammatory Agents, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, January 2020, Bentham Science Publishers,
DOI: 10.2174/1871523019666200102112017.
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