the correlation between EGFR and AR in Gastric cancer

What is it about?

we postulate the crosstalk between EGFR and AR pathways suggesting that GC cells could maintain the proliferation and survival utilizing alternative mechanism of activation to bypass androgen or EGF-dependent pathways. Therefore, our results propose a new therapeutic potential to suppress gastric cancer progression by targeting AR and subsequently EGFR pathways using a potent AR inhibitor such as Enzalutamide. Moreover, our study provided evidences elucidating a novel promising marker, simultaneous evaluation of EGFR and AR expression, which could properly predict prognosis of gastric cancer patients.

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Why is it important?

By targeting AR and EGFR using a potent AR inhibitor such as Enzalutamide, we postulate the possible crosstalk between EGFR and AR pathways in GC. Moreover, our study provided evidences elucidating a novel promising marker, simultaneous evaluation of EGFR and AR expression, which could properly predict prognosis of gastric cancer patients.