What is it about?
The designed compounds were synthesized and then evaluated in terms of their cytostatic activities against two human cell lines.
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Why is it important?
The objective of the current study is to design new lipophilic analogues of hydroxyurea with higher stability and better cell penetration.
Perspectives
Hydroxyurea (HU) is used to treat cancer. HU has a short half-life due to its small molecular weight and high polarity, therefore a high dosage of the drug should be used which introduces side effects and more rapid development of resistance. but or suggested structures, shape and hydrophobic character of substituents strongly affect the pharmacodynamics and pharmacokinetics of these type of ligands.
maryam iman
Baqiyatallah University of Medical Sciences
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This page is a summary of: Synthesis, in-silico and in-- vitro cytostatic activity of new lipophilic derivatives of hydroxyurea, Recent Patents on Anti-Cancer Drug Discovery, May 2018, Bentham Science Publishers,
DOI: 10.2174/1574892813666180517102255.
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