Thiosemicarbazone-Pt(II) Complex Causes a Growth Inhibitory Effect on Human Mesenchymal Stem Cells

What is it about?

We analysed how the platinum( II) complex (W8), endowed with important antitumor properties affect human bone marrow-derived Mesenchymal Stem Cells, (hMSCs). These cells are involved in tissue repair, immunomodulatory properties and also capacity for homing to injure-tumor sites in ovarian cancer.

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Why is it important?

Our results supports the notion of W8 triggers the energetic metabolism of hMSCs and adds an extra support by the results showing W8 relationship with the cellular copper ions. W8, acting in hMSCs, regulates in addition the inhibition of cell proliferation, the inhibition of tumor angiogenesis and metastasis