What is it about?
β-Glucosidase has a variety of biological functions. A structural model for potential β-glucosidase inhibitor has been proposed on the previous studies. According to the model, a series of novel benzimidazole derivatives bearing with an o-trihydroxyphenol and an additional phenyl ring on both sides of benzimidazole were designed, synthesized, and evaluated for their inhibitory activities against β-glucosidase (almond).
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Why is it important?
A series of new diaryl derivatives linked through benzimidazole have been randomly and rationally designed, synthesized, and evaluated for their inhibitory activities against β-glucosidase (almond). The proposed structural model provides a new strategy for the design of potent β-glucosidase inhibitors
Perspectives
Writing this article has been an immense pleasure for me, particularly because it features co-authors with whom I have enjoyed long-standing and fruitful collaborations over the years.
xu liu
Read the Original
This page is a summary of: Rational Design and Synthesis of Novel Benzimidazole Derivatives as Potential β-Glucosidase Inhibitors, Letters in Drug Design & Discovery, September 2024, Bentham Science Publishers,
DOI: 10.2174/1570180820666230822141514.
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