What is it about?
Prioritization of reported anti-HIV compounds, Design of analogs of top compound, Synthesis of designed compounds followed by anti-HIV activity evaluation.
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Why is it important?
This study showed that Tembamide which was reported to show potent anti-HIV activity against laboratory adapted strains of HIV-1, showed very weak activity against primary isolates of HIV-1.
Perspectives
The study indicates that before going to optimize compounds for particular activity
shiv gupta
National Institute of Pharmaceutical Education and Research
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This page is a summary of: In Silico Prioritization, Synthesis and In Vitro Evaluation of Tembamide Analogs for Anti-HIV Activity, Letters in Drug Design & Discovery, October 2017, Bentham Science Publishers,
DOI: 10.2174/1570180814666170419115526.
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