What is it about?
Over the past two decades, numbers of commonly used antibiotics have become less effective against certain bacterial infections, not only because of the side effects, but also due to emergence of drug resistant, like methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococcus faecium. Resistance to a number of antimicrobial agents (β-lactam antibiotics, Macrolides, Quinolones, and Vancomycin) among a variety of clinically significant species of bacteria is becoming increasingly major global problem. These pose a serious challenge to the scientific community hence emphasis has been laid on development of new antimicrobial agents.
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In view of the reported antimicrobial activity of various floroquinolone, and taking into consideration the structure activity studies of various substituted quinolones, which proved the importance of the C-7 substituents in the chemotherapeutic activity as well as many bulky substituted C-7 derivatives of floroquinolone proved to exhibit potent antimicrobial activities.
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This page is a summary of: Design, Synthesis and Molecular Docking of 1-Cyclopropyl-6- Fluoro-4-Oxo-7-{4-[2-(4-Substituted-Phenyl)-2-(Substituted)-Ethyl] -1-Piperazinyl}-1,4-Dihydroquinoline-3-Carboxylic Acid as an Antimicrobial Agents, Current Drug Discovery Technologies, October 2017, Bentham Science Publishers,
DOI: 10.2174/1570163814666170224110500.
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