What is it about?
Noxa is a member of the BH3-only subfamily of the larger BCL-2 family of apoptosis-regulating proteins. It is a pro-apoptotic protein that has been shown to play a role in the evolution of several types of cancers. This has led to the development of targeted therapies that modulate Noxa in the treatment of several types of cancer.
Featured Image
Why is it important?
Understanding how Noxa functions can offer additional therapeutic options in the treatment of several hard-to-treat cancers.
Perspectives
It is too early to determine if Noxa will live up to its promise in the treatment of cancer. Additional work is needed. This current review brings an up-to-date perspective of the experience so far.
Ghassan Dbaibo
American University of Beirut
Read the Original
This page is a summary of: Noxa: Role in Cancer Pathogenesis and Treatment, Current Cancer Drug Targets, March 2018, Bentham Science Publishers,
DOI: 10.2174/1568009618666180308105048.
You can read the full text:
Contributors
The following have contributed to this page
