What is it about?
Neostriatum is one of the brain areas that are not primarily affected in Alzheimer’s disease, according to classic regard of the disease. However, recent data emphasize the involvement of neostriatum, especially the head of the caudate nucleus, in the emergence of characteristic symptoms of the disease. Glutamatergic neurotransmission is a key component of striatal pathways. The present study is focused on glutamate receptors of striatal neurons on human caudate nucleus in normal aging and Alzheimer’s disease
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Why is it important?
The up-regulation of mGluR5 both in normal aging and Alzheimer’s disease is possibly associated with reorganization of neuronal connections, indicates the complexity of this receptor function and renders quite unpredictable the intervention and treatment of dementia with mGluR5 inhibitors or modulators.
Perspectives
This is an attempt to approach the complexity of synaptic alterations in Alzheimer's disease in correlation with normal ageing
Professor Stavros J Baloyannis or Balogiannis or Balojannis or Baloyiannis or Mpalogiannis
Aristotle University of Thessaloniki
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This page is a summary of: Glutamate Receptors in Human Caudate Nucleus in Normal Aging and Alzheimer’s Disease, Current Alzheimer Research, May 2013, Bentham Science Publishers,
DOI: 10.2174/1567205011310050002.
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