What is it about?
The developed hybrid modality has characteristic of Sendai viral membrane of delivering the payload through membrane fusion but the targeting ability is controlled by scFv. The research shows that this hybrid modality can escape intrinsic endosomal pathway of drug delivery by antibody.
Featured Image
Why is it important?
The research shows membrane fusion mediated cytosolic delivery of the payload as a major pathway of cellular internalization and the specificity is governed by scFv.
Perspectives
The research shows a strategy to avoid endosomal degradation of macromolecules ( therapeutic protein/ DNA etc.) maintaining specificity to cancer cells expressing antigen on the cell surface.
Mukesh Kumar
Thomas Jefferson University
Read the Original
This page is a summary of: Membrane Fusion Mediated Targeted Cytosolic Drug Delivery Through scFv Engineered Sendai Viral Envelopes, Current Molecular Medicine, May 2015, Bentham Science Publishers,
DOI: 10.2174/1566524015666150505155949.
You can read the full text:
Contributors
The following have contributed to this page
