Synthesis and Docking Study of Novel 4-Thiazolidinone Derivatives as Antibacterial Agents

What is it about?

A new series of 2-(5-(5-nitrothiophene-2-yl)-1,3,4-thiadiazole-2-ylimino)-5-arylidenethiazolidin- 4-one derivatives were designed and synthesized as new antibacterial agents. The results showed that the most potent compounds displayed antibacterial activity versus S.aureus, S.epidermidis, B.cereus and B.subtilis (MIC, 1.56-12.5 µg/ml). Some of the synthesized compounds had strong anti-H. pylori activity (inhibition zone >20 mm) in 25 μg disc. Docking studies determined suitable interactions and affinity of potent compounds with bacterial MUR B and H. pylori urease enzymes.

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Why is it important?

Different Gram-positive and Gram-negative bacteria cause very fatal infections and effective antibiotics are very limited as a result of multi-drug resistance, so the finding of new therapeutic agents is very important.