What is it about?
Farnesyl Transferase enzyme (FTase) plays a vital role in cell proliferation, but when overexpressed, it has the potential to cause uncontrolled cell growth and proliferation. Farnesyl transferase enzyme pathology described. Structure and function of FTase inhibitors are described. It's a review comprising of the available inhibitors and current clinical trials.
Featured Image
Why is it important?
I have mentioned about the available natural and synthetic inhibitors. (function, Ki value, chemical class, mechanism of action). I included drug development strategies based on Structure-Activity Relationship. This review can play an important role in the field of drug discovery.
Perspectives
Medicinal Chemists can develop potential new anti-cancer agents or modify the structure of the existing drugs to inhibit farnesyl transferase enzyme.
Mr Sounak Bagchi
Texas Tech University Health Sciences Center
Read the Original
This page is a summary of: Farnesyl trasnsferase inhibitors as potential anticancer agents, Mini-Reviews in Medicinal Chemistry, August 2018, Bentham Science Publishers,
DOI: 10.2174/1389557518666180801110342.
You can read the full text:
Contributors
The following have contributed to this page
