What is it about?
Natural plant antioxidants have been shown to mediate the oxidative stress-induced effects in PD, which has gained considerable attention in both in vitro and in vivo studies. This review provides an understanding of the oxidative stress-induced effects in PD by elucidating the underlying events contributing to oxidative stress and explore the potential use of polyphenols in improving the oxidative status in PD.
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Why is it important?
Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the human midbrain. Various ongoing research studies are competing to understand the pathology of PD and elucidate the mechanisms underlying neurodegeneration. Current pharmacological treatments primarily focused on improving dopamine metabolism in PD patients, despite the side effects of long-term usage. In recent years, it is recognized that oxidative stress-mediated pathways lead to neurodegeneration in the brain, which is associated with the pathophysiology of PD.
Perspectives
Plant antioxidants possess great potential for future investigation to target Parkinson's Disease
Suet Lee Hor
Read the Original
This page is a summary of: Plant Polyphenols as Neuroprotective Agents in Parkinson’s Disease Targeting Oxidative Stress, Current Drug Targets, April 2020, Bentham Science Publishers,
DOI: 10.2174/1389450120666191017120505.
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