What is it about?
Thioredoxin-interacting protein (TXNIP) has attracted considerable attention due to its wide-ranging functions affecting several aspects of energy metabolism. TXNIP acts as an important regulator of glucose and lipid metabolism through pleiotropic actions including regulation of β-cell function, hepatic glucose production, peripheral glucose uptake, adipogenesis, and substrate utilization. Overexpression of TXNIP in animal models has been shown to induce apoptosis of pancreatic β-cells, reduce insulin sensitivity in peripheral tissues like skeletal muscle and adipose, and decrease energy expenditure. On the contrary, TXNIP deficient animals are protected from diet-induced insulin resistance and type 2 diabetes. Consequently, targeting TXNIP is thought to offer novel therapeutic opportunities and TXNIP inhibitors have the potential to become a powerful therapeutic tool for the treatment of diabetes mellitus.
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Perspectives
Here we summarize the current state of our understanding of TXNIP biology, highlight its role in metabolic regulation, and raise critical questions that could help future research to exploit TXNIP as a therapeutic
Dr Sameer Mohammad
KAIMRC, NGHA
Read the Original
This page is a summary of: TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook, Current Drug Targets, June 2017, Bentham Science Publishers,
DOI: 10.2174/1389450118666170130145514.
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