What is it about?
Viruses are the obligatory most devastating pathogens that replicate very fast and may affect any metabolic and physiological function of the host cell. Once the viruses highjack the host cell machinery, start growing very fast at the cost of the cell, that becomes a great challenge to develop a universal and common treatment against viral pathogens, in contrast to bacterial pathogens. Virus-host interaction is a complex phenomenon that often is virus- and host cell-specific.
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Why is it important?
Exciting new insights into the molecular pathogenesis and host-virus interactions have been gained over the past few decades. These advances have enabled researchers to design better antiviral drugs, therapeutics and innovative targeted delivery systems for precise delivery drugs into host tissues/organs. The host-pathogen interactions at cellular as well molecular levels promising new antiviral drugs and immuotherapeutics targeted to important viral diseases, including herpes, HIV, influenza and many more. Recent development of several innovative anti-viral drug delivery systems have shown great promises by which the antiviral drugs can be effectively delivered to desired tissues/organs to enhance the efficacy of antiviral intervention resulting in minimizing the drug doses their by minimizing the side effects induced by drug.
Perspectives
The title of the article was selected based on the need of the hour keeping in view the incresing incidences of emergence of new viral pathogens and also emergence of drug resistance in already prevalent viruses. The idea provekes for continuous search for more effective and universal anti-viral prevention and control agents through research in the field of drug discovery and vaccinology. Identifying new drug targets viral/host factors will help in developing better antiviral interventions. Though the article is slightly lenghty to read but i hope coulourful figures make it easy to understand the action of new drugs.
Minakshi Prasad
Read the Original
This page is a summary of: Virus-Host Interactions: New Insights and Advances in Drug Development Against Viral Pathogens, Current Drug Metabolism, January 2018, Bentham Science Publishers,
DOI: 10.2174/1389200218666170925115132.
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