What is it about?
The effects of DHPs on mitochondria of different cellular origin (hepatic, cardiac, neuronal, brain, muscle) were observed. Methodology: It were reported about several accepted and original methods used in the studies of mitochondrial bioenergetics (respiratory activity, respiratory control ratio – RCR and membrane potential), lipid peroxidation, detection of oxygen and nitrogen radical species, enzyme activity (activities of succinate-, malate-, glutamate-, NADH-dehydrogenases, δ(delta)-aminolevulinic acid synthetase), membrane physico-chemical properties. Conclusion: DHPs could affect mitochondria solely as well as in combination with other drugs either for the enhancement or for the weakening of their mutual effects, or even being active as one of the essential parts of large complex molecules. Accordingly, bimodal effects on mitochondria (improvement or endangerment of mitochondrial functions) obtained by various DHPs are of high importance for the overall bioactivities of DHPs.
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Why is it important?
Bbimodal effects on mitochondria (improvement or endangerment of mitochondrial functions) obtained by various DHPs are of high importance for the overall bioactivities of 1,4-dihydropyridines
Perspectives
This finding about 1,4-dihydropyridines as perspective tools for mitochondrial medicine will expand the research of mitochondrial effects of newly synthesized DHP and related compounds, as well 1,4-dihydropyridines known as commercial drugs
Astrida Velena
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This page is a summary of: 1,4-Dihydropyridines as Tools for Mitochondrial Medicine Against Oxidative Stress and Associated Metabolic Disorders, Current Organic Chemistry, October 2017, Bentham Science Publishers,
DOI: 10.2174/1385272821666170207104206.
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