What is it about?
Heterocycles are usually assembled from more than two starting materials. For making heterocycle formation smoothly and in a one-pot fashion we established the catalytic generation of alkynones, i.e. reactive Michael systems, before adding further components to the reaction mixture to selectively form the compound class of choice. By the substitution pattern of the starting materials the structural and functional diversity of these efficiently formed heterocycles are varied in a wide range.
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Why is it important?
Heterocycles are the most important small molecules, since the contain functionality that is of utmost importance for their biological or materials properties. Concise, diversity-oriented heterocycle synthesis in a one-pot fashion enhance the establishing of substance libraries, which are very important to establish structure-property-function relationships of molecular materials, ranging from life sciences over molecular electronics to materials sciences.
Perspectives
One-pot methodologies are designed to facilitate synthetic efforts in an efficient and efficacious way. There is no need for accumulating important intermediates in multistep syntheses if a multicomponent reaction (domino, sequential or consecutive) can be employed to generate the structures of interest from readily avialable starting materials by smartly selecting proper reaction conditions to concate the steps into a one-pot scenario.
Professor Thomas J J Müller
Heinrich-Heine-Universitat Dusseldorf
Read the Original
This page is a summary of: Multi-component Heterocycle Syntheses via Catalytic Generation of Alkynones, Current Organic Chemistry, December 2009, Bentham Science Publishers,
DOI: 10.2174/138527209789630479.
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