What is it about?
The main otilonium bromide action consists in the blockade of Ca2+ entry through L-type Ca2+ channels and interference with intracytoplasmatic Ca2+ mobilization necessary for SMC contraction, thus preventing excessive bowel contractions and abdominal cramps useful to treat irritable bowel syndrome.
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Why is it important?
It is an extensive review of the studies so far carried ut on the spasmolytic otilonium bromide.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to explain how otilonium bromide can help IBS patients.
Dr. Stefano Evangelista
Read the Original
This page is a summary of: Otilonium Bromide: A Drug with a Complex Mechanism of Action, Current Pharmaceutical Design, August 2018, Bentham Science Publishers,
DOI: 10.2174/1381612824666180507122935.
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