What is it about?
Obese individuals have higher rates of cancer incidence and cancer-related mortality. The worse outcomes observed are caused by altered physiology in obesity and its impact on pharmacokinetics, increased risk of underdosing and treatment-related toxicity.
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Why is it important?
Our findings show that actual total body weight dosing appears to be a better approach to dosing anticancer drugs in both adults and children when aiming for curative results, showing no difference in toxicity and no limitation in treatment outcomes when compared to adjusted doses.
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This page is a summary of: Chemotherapy and Anticancer Drugs Adjustment in Obesity: A Narrative
Review, Current Medicinal Chemistry, March 2023, Bentham Science Publishers,
DOI: 10.2174/0929867329666220806140204.
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