What is it about?
In this article we summarize research findings indicating that chylomicron and VLDL remnants, the triglyceride-rich lipoprotein species in circulation, can accumulate in the arterial wall. There they have the potential to induce local inflammation, lipid accumulation, and lead to formation of atherosclerotic lesions. The processes are similar to those happening with LDL, the cholesterol-carrying lipoproteins.
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Why is it important?
The role of triglyceride-rich lipoproteins in the development of atherosclerosis has recently emerged because of clinical findings. We wanted to describe the biochemical mechanisms behind the clinical findings.
Perspectives
The topic was timely and directly related to our work. Therefore, it was a pleasure to write the article together with the co-authors.
Dr Katariina Öörni
Wihuri Research Institute
Read the Original
This page is a summary of: Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall, Current Medicinal Chemistry, May 2019, Bentham Science Publishers,
DOI: 10.2174/0929867325666180530094819.
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