What is it about?
Endosome entrapment is a key barrier to the success of non-viral gene delivery systems. This review details various methods that have been investigated to improve the escape of delivered genes/oligonucleotides from endosomes following their cellular uptake.
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Why is it important?
Endosome escape is a very important barrier to the success of non-viral gene delivery systems. This review provides important examples of successful approaches to improve the endosome escape of genes. This information is essential for the successful development of non-viral gene delivery systems.
Perspectives
This is an outstanding review of the approaches that have been investigated to improve the endosome escape of non-viral gene delivery systems.
Dr Peter Michael Moyle
University of Queensland
Read the Original
This page is a summary of: Endosome Escape Strategies for Improving the Efficacy of Oligonucleotide Delivery Systems, Current Medicinal Chemistry, September 2015, Bentham Science Publishers,
DOI: 10.2174/0929867322666150825162941.
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