What is it about?
Several consequencies of AT1R overactivation due to the binding of spike protein on ACE2 have been described, here we enlight precise consequences of this overactivation through ADAM-17 pathway: NK cells impairement, cleavages of the extracellular domain of CAMs, especially in relation with cancers concerns.
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Why is it important?
ADAM-17 overactivation can be linked to viral persistence. http://dx.doi.org/10.13140/RG.2.2.26302.91201
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This page is a summary of: Renin-Angiotensin System Dysregulation: ADAM17 Activation Consequences Related to SARS-CoV-2, Infectious Disorders - Drug Targets, February 2025, Bentham Science Publishers,
DOI: 10.2174/0118715265299597240422102455.
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