What is it about?
indole-based compounds are considered an important and powerful motif for scientists during their fight against this widespread and life-threatening disease, i.e., cancer. Many anti-cancer agents that pertain to an indole scaffold have entered the pre-clinical and clinical stages, and there are too many FDA-approved drugs. we focused on the merits of the indole nucleus which may motivate researchers to investigate this nucleus. However, some obstacles may arise during drug development using indoles, such as selectivity. Continuous research and the use of modern drug design approaches and screening technologies might help overcome such obstacles
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Photo by National Cancer Institute on Unsplash
Why is it important?
Indole scaffold has too many mechanisms to exert its anti-cancer activity, and there are too many FDA-approved drugs with indole-based structures. This may motivate researchers to focus on this nucleus, and we showed too many examples to enthusiast them toward this topic.
Perspectives
Writing this article was a great pleasure as I worked with cooperative co-authors and this topic was my main point during the Master's as I could publish an article to defend my thesis which mainly about indole and oxindole. By the end of writing the manuscript, I guessed that many people would be interested in this topic and this nucleus.
Mr. Momen Ramadan Fareed Mohamed
Szegedi Tudomanyegyetem
Read the Original
This page is a summary of: Anti-Tumor Activity of Indole: A Review, Letters in Drug Design & Discovery, December 2024, Bentham Science Publishers,
DOI: 10.2174/0115701808288928240226104445.
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