What is it about?
Article Focus: This article explores the rising prevalence of immune-mediated bowel diseases (IMBD), such as ulcerative colitis and Crohn's disease, emphasizing the dynamic interplay between intestinal parasites and the gut microbiome. It highlights how these relationships influence disease progression and potential therapeutic approaches.
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Why is it important?
Key Highlights for Redears: 1. Gut Microbiome and IMBD: -The microbiome’s role in maintaining intestinal and immune balance. -Dysbiosis contributes to inflammation, abnormal immune responses, and IMBD pathogenesis. 2. Impact of Intestinal Parasites: -Parasites influence microbiome composition, diversity, and activity. -Necator americanus shows therapeutic potential through immune modulation. -Strongyloides stercoralis may exacerbate IMBD-like symptoms. 3. Therapeutic Insights: -Understanding these interactions could inspire innovative treatments targeting gut microbiota restoration.
Perspectives
Key Highlights for General Readers: -IMBD, including ulcerative colitis and Crohn's disease, are rising globally due to complex causes. -Parasites and gut bacteria play a surprising role in influencing these diseases. -Some parasites might help reduce symptoms, while others can make them worse. -Research in this area may lead to new ways to manage and treat IMBD effectively. This article bridges advanced research with practical insights, offering readers a comprehensive understanding of this fascinating topic.
Dr. Manish Kumar Gautam
Assam Down Town University
Read the Original
This page is a summary of: Immune-mediated Bowel Disease: Role of Intestinal Parasites and Gut Microbiome, Current Pharmaceutical Design, December 2024, Bentham Science Publishers,
DOI: 10.2174/0113816128326270240816075025.
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