Selection of a Single Chain Variable Fragment Antibody (scFv) against Subtilisin BRC

What is it about?

In recent years, cardiovascular diseases (CVDs) have been a major cause of death worldwide. Vein thromboses are one kind of CVDs, which inevitably lead to a high death rate owing to their origin from the disorders of the heart and blood vessels. For example, deep vein thromboses and pulmonary embolisms can be dislodged and move to the heart and lungs, which present a threat to health. It has been reported that thrombotic embolisms are responsible for the death of more than 26 million people worldwide annually .In addition, the death rate may rise in the future because of the increasingly unhealthy eating and living habits. Therefore, the discovery of effective treatments for thrombotic diseases is important to decrease the morbidity and mortality associated with thrombosis.

Featured Image

Why is it important?

The focus of this study was the selection of a single chain variable fragment antibody (scFv) against subtilisin BRC, a fibrinolytic enzyme using phage display, and to characterize the interaction between the antibody and subtilisin BRC.