What is it about?
Underlying the development of autoimmune diseases is an imbalance between Th17 and regulatory T lymphocytes. We have shown that IL-23, IL-31 and IL-33 are involved in the course of some endocrine autoimmune diseases, such as Hashimoto's thyroditis, Graves' disease or Addison's disease.
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Why is it important?
The involvement of IL-23, IL-31 and IL-33 has been confirmed in the course of many autoimmune diseases. Of the endocrine diseases, an increasing amount of data points to the involvement of these cytokines in the course of Hashimoto's thyroiditis and Graves's disease. However, there are no data on the involvement of these cytokines in the course of Addison's disease. Our work sheds light on the role of these cytokines also in Addison's disease.
Perspectives
The development of immunology and the use of immunological drugs in the treatment of diseases is an extremely intensively developing field of medicine. This work makes a small contribution to the elucidation of the pathomechanism of some endocrine diseases. It is hoped that an understanding of the mechanisms of development of endocrine autoimmune diseases will allow not only the use of hormone replacement in patients, but also effective treatment.
Szymon Janyga
Medical University of Silesia
Read the Original
This page is a summary of: Interleukin (IL)-23, IL-31, and IL-33 Play a Role in the Course of Autoimmune
Endocrine Diseases, Endocrine Metabolic & Immune Disorders - Drug Targets, April 2024, Bentham Science Publishers,
DOI: 10.2174/1871530323666230908143521.
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