What is it about?
Roles for adipose tissues in energy metabolism, health maintenance and disease onset have been established. Evidence indicates that white, brown and beige fats are quite different in terms of their cellular origin and biological characteristics, and these differences are of great significance in targeting adipocytes so as to study the pathogenesis and prevention strategies of related diseases. The biotransformations of white, brown and beige fat cells constitute an intriguing topic worthy of further study, and the molecular mechanisms underlying the biotransformations of white, brown and beige fat cells remain to be elucidated. Hence, we herein collected evidence from studies on adipose tissue or adipocytes, and we extracted the structural features, biologic functions, and biotransformations of adipose tissue/adipocytes. The aim of the present review was to summarize the latest research progress, and to propose novel research directions with respect to adipose tissue and adipocytes. We posit that this work will provide new insights and opportunities in the effective treatment strategies for obesity, diabetes and other lipid-related diseases, and it will contribute to our knowledge of the basic biologic underpinnings of adipocyte biology.
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Photo by National Cancer Institute on Unsplash
Why is it important?
The aim of the present review was to summarize the latest research progress, and to propose novel research directions with respect to adipose tissue and adipocytes. We posit that this work will provide new insights and opportunities in the effective treatment strategies for obesity, diabetes and other lipid-related diseases, and it will contribute to our knowledge of the basic biologic underpinnings of adipocyte biology.
Perspectives
Writing this article was a great pleasure. We hope this article leads to a more in-depth and extensive study of fat, and facilitates the elucidation of the processes involved in the evolution from biologic molecules to cells, from cells to tissues and organs, and from tissues and organs to animals and humans; and allows us to discern the basic regulatory underpinnings of adipocyte biology.
Maosheng Yang
Jishou University
Read the Original
This page is a summary of: A Review of Structural Features, Biological Functions and Biotransformation
Studies in Adipose Tissues and an Assessment of Progress and Implications, Endocrine Metabolic & Immune Disorders - Drug Targets, January 2023, Bentham Science Publishers,
DOI: 10.2174/1871530322666220827145241.
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