What is it about?
Crocin exhibited anti-inflammatory properties where NF-kB, among other inflammatory markers, was inhibited. In vitro analysis confirmed crocin effect in HepG2 by arresting the cell cycle at S and G2/M phases, inducing apoptosis and down regulating inflammation. Network analysis identified NF-kB as a potential regulatory hub, and therefore, a candidate therapeutic drug target
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Why is it important?
In summary, this study demonstrated the effects of crocin in chemically-induced HCC animal model and promoting crocin as a potential HCC drug. Crocin inhibited the formation of FAH in DEN-induced HCC models, which was accompanied with reduced oxidative stress and restored levels of antioxidants. Moreover, treatment with crocin decreased the activity of inflammatory markers, COX-2, iNOS, NF-kB, TNF- and its receptor p-TNF-R1; in addition to a reduction in the number of Kupffer cells and macrophages. Crocin exhibited anti-proliferative and pro-apoptotic properties when administrated to DEN-treated rats
Perspectives
The preclinical investigations presented here clearly demonstrated the crocin’s anti-inflammatory, proapoptotic and antiproliferative effects against liver cancer. Further studies are currently underway in our lab to assess the effects of crocin (along with other natural occurring ingredients) against liver cancer in combinations with other commonly used chemotherapeutic drugs.
Dr Alaaeldin A Hamza
National Organization for Drug Control and Research
Read the Original
This page is a summary of: Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In vivo, In vitro and Network Analyses, Recent Patents on Anti-Cancer Drug Discovery, February 2016, Bentham Science Publishers,
DOI: 10.2174/1574892810666151102110248.
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