Synthesis of Bioactive N-based compounds using Microwaves.

What is it about?

Our environment is continuously changing everyday, so there is an urgent need for sustainable, eco-friendly, and safer chemistry techniques. To minimize environmental pollution, green chemistry principles came into the picture in recent years. Over the years, microwave heating has evolved as a greener technique in organic synthesis. The advantages of the safe and environment-friendly MW heating approach include a simple experimental setup, products of high purity with high yields, solvent-free reactions, short reaction times, elimination of the side products, and a decrease in the rate of by-product formation. Nitrogen based heterocycles are important as they are present in natural products and have widespread applications in pharmaceutical industries as well. These N-heterocycles are part of many biologically active molecules. In the present work, the author had compiled the developments in microwave assisted synthesis of biologically important N-heterocycles in the last 2 years (2020-21).

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Photo by National Cancer Institute on Unsplash

Photo by National Cancer Institute on Unsplash

Why is it important?

In comparison to other synthetic methods, microwave assisted synthesis enables the selective alteration of reaction conditions for product formation. The reactions were found to be cleaner, faster, yielding higher products of high purity, environmentally friendly. The molecules reported in the review are extensive and the review will enhance our knowledge on the application of microwaves. It is beyond doubt that use of MW assisted reactions involves the diversification of bioactive N scaffolds. It is hoped that this review will serve to stimulate new thoughts towards rational design of more active and less toxic N-based medicinal drugs.

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