What is it about?
We have proposed the GC-NSF(a) hypothesis for the formation of an entirely new (EntNew) gene, which suggests that an EntNew gene is generated from a non-stop frame on the antisense strand of a GC-rich gene (GC-NSF(a)). NSF(a) is the non-stop frame codon sequence on the antisense strand in the reading frame corresponding to the gene on the sense strand.
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Why is it important?
Diverse organisms with multiple kinds of genes inhabit most of the Earth. As is already known, these organisms have a fundamental biological system comprising genes that make up the genetic code and proteins. Therefore, an important area of research would be the mechanism underlying the production of an entirely new (EntNew) gene or the first protein belonging to a new family.
Perspectives
I consider that this GC-NSF(a) hypothesis is an important one to be related in the [GADV]-protein world hypothesis that solves the mystery on the origin of life. I hope that this article makes contribute to development of the study on the origin of life.
Ryoko Oi
G&L Kyosei Institute
Read the Original
This page is a summary of: Direct Evidence for GC-NSF(a) Hypothesis on Creation of Entirely New Gene/Protein, Current Proteomics, January 2018, Bentham Science Publishers,
DOI: 10.2174/1570164614666170619090537.
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