What is it about?
Autophagy is a homeostatic process, which involves recycling of intracellular materials. Alterations in cellular autophagy is common in cancer. In this paper, we discuss autophagy in cervical cancer with a focus on HPV infection and cervical cancer progression in the environment of autophagy.
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Why is it important?
To understand the role of autophagy in cervical cancer cells, various contexts need to be carefully identified such as stage of the disease, cell type, activation or deactivation of of specific genes etc. In future, more studies are warranted in order to define these contexts to harness antitumor potential of this pathway and to design novel therapies which target it in cervical cancer.
Perspectives
Autophagy plays contrasting roles as it leads to cervical cancer progression as well as dormancy. This article discusses various mechanisms of regulation of autophagy in cervical cancer cells which can provide insights for harnessing its potential for design of therapeutic strategies against cervical cancer.
Sonal Manohar
Read the Original
This page is a summary of: Molecular Milieu of Autophagy in Cervical Cancer and its Therapeutic
Implications, Current Cancer Drug Targets, December 2023, Bentham Science Publishers,
DOI: 10.2174/1568009623666230412104913.
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