Calixarene derivatives production and demand in the biomedical area

What is it about?

Calixarenes are recognized as a remarkable macrocycle host due to their unique structure and outstanding properties. The fundamental chemical structure of calixarene makes it ideal for molecular recognition, including cations, transition metal ions, heavy metals ions, and neutral molecules. Optimal molecular interaction with variety of guest molecules can be achieved by modifying the upper and lower rims of calixarene. Calixarene has attracted interest as a cancer treatment due to its sensitivity to a variety of stimuli, stability, avoidance of non-specific cell uptake, and ability to reach the intended target for treatment effect. It also poses biocompatibility and innocuousness. This review focuses on the synthesis and drug delivery properties of calixarene

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Photo by Terry Vlisidis on Unsplash

Photo by Terry Vlisidis on Unsplash

Why is it important?

The review is focuses on three major types of calixarene that are extensively studied, which are calix[4]arene, calix[6]arene, and calix[8]arene. The three primary calixarenes have been proven to successfully trap the drugs. Even though they came from the same macrocyclic family however each of them posses and exhibit different properties in terms of the cytotoxicity, stability, and sustained release profile. Thus this review helps in determining the ideal host among three major calixarene for a specific guest and the most lease toxic or non-toxic host.

Perspectives