What is it about?
This study obtained the bioactive ingredients of the LQHBG and the predictive targets of DR and then used network pharmacology to manifest the correlations between the Chinese herbal compound LQHBG and DR and the potential synergistic mechanisms of the LQHBG for the treatment of DR, providing new ideas for drug treatment.
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Why is it important?
First, we used the network pharmacology method to reveal the potential targets and possible pharmacodynamic mechanisms of the chemical components of the Chinese herbal compound Lingqihuangban Granule in the treatment of diabetic retinopathy to provide a new idea for the treatment of diabetic retinopathy by integrating the theories of traditional Chinese medicine and western medicine. Second, combined with network platforms and the research literature, we deeply explored the targets and pathways of Lingqihuangban Granule in treating diabetic retinopathy and obtained the potential pathways and mechanisms of action through the analysis of multiple platforms and the verification of molecular docking, paving the way for further study of the molecular regulation and the interaction relationships.
Perspectives
DR is characterized by structural and functional changes that are affected by multiple factors. The current clinical studies identified new targets for the treatment of DR and confirmed that the traditional Chinese medicine components acting on these potential targets play important roles in the prevention and treatment of DR. In this study, the bioactive components and targets of the LQHBG in treating DR were analyzed and predicted through a network pharmacology method, while the mechanisms of action of key genes and pathways were analyzed through bioinformatics methods. It can be seen from the network diagram of bioactive components–targets and pathway analysis that quercetin is most the common component of the four single drugs in the LQHBG, which act together on the core gene of ALB, reflecting the synergistic effects of compound Chinese medicine components. Each herb consists of different bioactive ingredients, acting on diverse drug targets, referred to as the AGE-RAGE, HIF-1a, PI3K Akt, MAPK, and NF-kappa B signaling pathways, treating DR from different therapeutic aspects of the circulation, metabolism, inflammation, and aging, embodying the complementary effects of compound Chinese medicine in the treatment of DR with multiple components, multiple targets and multiple approaches, providing a new idea for the treatment of DR with complex pathogenesis. Because the results of this study were only obtained from available databases and the obtained pathways were relatively wide, failing to fully elucidate the molecular regulation and interaction relationships, the next step will be undertaking in vitro experiments and performing analysis of the biological technology, further verifying the accuracy of the targets of the Chinese herbal compound LQHBG and will be focusing on each single pathway to study the molecular regulation and interaction relationships, further exploring the specific mechanisms of action of this Chinese herbal compound in treating DR.
Shuai He
Read the Original
This page is a summary of: Exploration of the Potential Mechanisms of Lingqihuangban Granule for
Treating Diabetic Retinopathy Based on Network Pharmacology, Combinatorial Chemistry & High Throughput Screening, January 2023, Bentham Science Publishers,
DOI: 10.2174/1386207325666220407112018.
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