What is it about?
In summary, Cancer highlighting the major types of concern—breast, lung, and liver cancer—according to GLOBOCAN 2022 data. It emphasizes the potential of dietary natural substances, particularly phytochemicals like curcumin, for their low toxicity and beneficial effects in cancer prevention and treatment. The review first examines existing research on curcumin effects on these cancers through various molecular pathways. It then focuses on curcumin and its derivatives, detailing their interactions with specific proteins identified through molecular docking studies. These studies help in designing new curcumin derivatives. However, further research is needed to fully understand their mechanisms of action.
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Why is it important?
The importance of investigating dietary natural substances, such as curcumin, for cancer treatment. Cancer, marked by uncontrolled cell growth, poses a significant health threat globally. Natural substances are valued for their low toxicity and beneficial effects. Curcumin, a compound derived from turmeric, has shown promise in combating cancer through various molecular pathways. Understanding curcumin interactions at the molecular level and developing new derivatives could enhance cancer treatment strategies. Continued research is crucial to fully explore and validate curcumin's potential and mechanisms of action.
Perspectives
Current Challenges: Curcumin, despite its potential, suffers from low bioavailability and poor pharmacokinetics. Structural modifications have been made to enhance its effectiveness.Targeting Signaling Pathways: The review discusses how modified curcumin affects various cancer-related signaling pathways and the importance of directly targeting these pathways to improve treatment outcomes.Innovative Development: It underscores the need for designing and synthesizing new curcumin derivatives and structures to advance therapeutic applications.
Firdous Fatima
Dr HariSingh Gour Vishwavidyalaya, Sagar, MP, India
Read the Original
This page is a summary of: Curcumin and its Derivatives Targeting Multiple Signaling Pathways
to Elicit Anticancer Activity: A Comprehensive Perspective, Current Medicinal Chemistry, July 2024, Bentham Science Publishers,
DOI: 10.2174/0929867330666230522144312.
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