Endosome Escape Strategies for Improving the Efficacy of Oligonucleotide Delivery Systems

Y. Wan, P.M. Moyle, I. Toth
  • Current Medicinal Chemistry, September 2015, Bentham Science Publishers
  • DOI: 10.2174/0929867322666150825162941

Strategies to improve the escape of gene delivery platforms from endosomes

What is it about?

Endosome entrapment is a key barrier to the success of non-viral gene delivery systems. This review details various methods that have been investigated to improve the escape of delivered genes/oligonucleotides from endosomes following their cellular uptake.

Why is it important?

Endosome escape is a very important barrier to the success of non-viral gene delivery systems. This review provides important examples of successful approaches to improve the endosome escape of genes. This information is essential for the successful development of non-viral gene delivery systems.

Perspectives

Dr Peter Michael Moyle (Author)
University of Queensland

This is an outstanding review of the approaches that have been investigated to improve the endosome escape of non-viral gene delivery systems.

The following have contributed to this page: Dr Peter Michael Moyle