Self-Adjuvanting Lipopeptide Vaccines

Peter Moyle, Istvan Toth
  • Current Medicinal Chemistry, February 2008, Bentham Science Publishers
  • DOI: 10.2174/092986708783503249

The incorporation of lipids into peptide vaccines to stimulate the immune system

What is it about?

An outstanding and highly cited review into the use of lipids to stimulate the immune system to mount immune responses against peptide-based vaccines.

Why is it important?

We need new vaccines, and lipid-based adjuvants have proven to be extremely efficient at stimulating various types of immune responses including antibodies and cytotoxic lymphocytes. Further, when combined with peptide antigens, lipid-based adjuvants can be readily incorporated into the vaccine during the routine synthetic processes.

Perspectives

Dr Peter Michael Moyle (Author)
University of Queensland

The conjugation of lipid-based adjuvants with peptide antigens offers an exciting means to produce potent, self-adjuvanting vaccines, with the potential for needle free mucosal delivery.

The following have contributed to this page: Dr Peter Michael Moyle