What is it about?
To investigate the anticonvulsant and adjuvant effects of the bioflavonoid and explore behavioral responses of Orientin (Ore) on kindled mice induced by pentylenetetrazole [PTZ]. Albino Swiss mice weighing 20-30 g were divided into nine groups [n=6]. Prior to the PTZ dose, alternatively, Ore [10 mg/kg, i.p.] was given for 7 days, dissolved in 6% w/v carboxymethylcellulose [CMC] salt. On the 7th day, saline was solubilized with Lamotrigine [Lmt], Phenobarbital [Pb], and Gabapentin [Gbp] and administered as separate intraperitoneal [i.p.] injections 30 minutes prior to the PTZ dose. For the development of kindling seizures in mice, PTZ [30 mg/kg, i.p.] was delivered to all the mice for 12 days alternatively, until the animals appeared to be developing full motor muscle jerking seizures. After the animals have survived complete motor seizures.
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Why is it important?
Orientin has neuroprotective potential to reduce the frequency of seizures in epilepsy. The study also emphasizes the significant reduction of epileptic fits and exhibits positive therapeutic results of phenobarbital with Ore as an adjuvant role, raising hopes that Ore may have the potential to supplement the drug with phenobarbital in therapeutic strategies for generalized epilepsy and associated concerns.
Perspectives
Oxidative stress in epilepsy can be minimized by Ore. When the development of reactive oxygen species [ROS] and their chronic damage ability exhibit detoxification fall out of equilibrium [29][30]. Neurotoxicity, neuroinflammation, ischemia, and dementia are a few of the oxidative stress that have a significant impact on neurodegenerative disorders of the brain. According to the concept, oxidative harm might result from the excessive stimulus that occurs during seizures [31]. Mitochondrial destruction may also occur as a consequence of aberrant neuronal charge liberations, extreme glutamate production, NMDA receptor excitation, and oxidative pathways [32-34]. The widely available pharmacological animal model of seizures is being explored in the current study to develop this protocol.
Dr. Aman Shrivastava
GLA University
Read the Original
This page is a summary of: Neuroprotective Potential of Orientin with Antiepileptic Drugs against
Pentylenetetrazole-induced Kindling Model and Evaluation of Behavioral
Assessment in Mice, Current Enzyme Inhibition, March 2024, Bentham Science Publishers,
DOI: 10.2174/0115734080276565231024054936.
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