What is it about?
This article reviews updated clinical studies addressing aldosterone's role in affecting cardiac structure and function in the general population, essential hypertension, primary aldosteronism, heart failure, and atrial fibrillation.
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Why is it important?
Aldosterone might cause several cardiac structural remodelling and dysfunction, including LVH and diastolic dysfunction. These aldosterone induced cardiac changes can be independent of their impact on blood pressure. Thus, it is crucial to address aldosterone excess and not just blood pressure in the relevant clinical conditions. MR blockade could effectively decrease or reverse these harmful consequences.
Perspectives
Findings also favor the notion that aldosterone antagonists might even help patients without hyperaldosteronism delay or perhaps halt the occurrence of abnormal geometric patterns and diastolic dysfunction, implying the need for more observational and interventional research in this area.
EKHLAS AL-HASHEDI
First Affiliated Hospital of Xi’an Jiaotong University
Read the Original
This page is a summary of: Aldosterone Effect on Cardiac Structure and Function, Current Cardiology Reviews, July 2024, Bentham Science Publishers,
DOI: 10.2174/011573403x281390240219063817.
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