Pathophysiology of Schizophrenia

What is it about?

This article aims to provide a comprehensive understanding of schizophrenia’s intricate pathophysiology by synthesizing diverse mechanistic threads into a novel circuit-based framework that elucidates the disorder’s neurobiological underpinnings. It aims to bridge preclinical and clinical insights to clarify how heterogeneous pathways converge to shape the symptomatic spectrum of schizophrenia, while curating a comprehensive biomarker compendium to guide precise diagnostics and therapeutic innovation.

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Photo by Sander Sammy on Unsplash

Photo by Sander Sammy on Unsplash

Why is it important?

Schizophrenia remains a profoundly complex disorder, defined by a convergence of disrupted neurobiological processes that challenge conventional treatment paradigms. This review synthesizes evidence on the pivotal role of Nmethyl- D-aspartate receptor (NMDAR) hypofunction, which orchestrates a cascade of dysregulations across glutamatergic, dopaminergic, and GABAergic systems.