What is it about?
Vascular growth is known to be triggered by the inflammatory factor VEGF that increases the amount of urokinase receptor, which promotes vessel sprouting into the tissue. The article shows that the mechanism of urokinase receptor increase caused by VEGF is similar to the inflammatory factors - TNFa and IL-1b.
Featured Image
Photo by Robina Weermeijer on Unsplash
Why is it important?
In this paper we demonstrated possible molecular mechanisms of uPAR inflammatory response, linking TNF-alpha, IL-1beta, and VEGF signaling pathways with transcriptional regulation of the PLAUR gene. The obtained data can make a significant contribution to the development of new drugs aimed at the regulation of angiogenesis.
Perspectives
It should be noted that the proximal enhancer is endothelial-specific and responsible for the PLAUR expression pattern in endothelial cells. This means that endothelium-specific regulation of uPAR expression is potentially possible.
Irina Beloglazova
National Medical Research Center of Cardiology named after academician E.I. Chazov
Read the Original
This page is a summary of: Endothelial-specific Enhancer as a Cis Element of PLAUR Regulation
by TNF-alpha, IL-1beta, and VEGF, Current Pharmaceutical Design, June 2024, Bentham Science Publishers,
DOI: 10.2174/0113816128296376240424072322.
You can read the full text:
Contributors
The following have contributed to this page
