What is it about?
Early detection of leprosy can be an effective intervention to halt the spread of disease and its progression to more severe polar forms. This article dives deep into the M. leprae specific cell wall proteins and discusses in brief the methodologies that have been used to isolate and identify them. The article also discovers the evolution in methodologies for cell wall biomarkers isolation and characterization over the years.
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Why is it important?
Cell wall proteins of M. leprae, the causative agent of leprosy can be used for identification of the patients in their early phases of infection. Point of care tests based on identification of these cell wall proteins specific to M. leprae can be developed and optimized for early detection of the disease in remote areas and thus can be an effective tool for leprosy eradication programs.
Perspectives
This study is highly significant in the field of infection proteomics, however, apart from the already known cell wall biomarkers, interaction of these pathogen proteins with that of host cell proteins can be studied further and may provide some highly significant insights. In addition to this, development of recombinant proteins shall also be taken into consideration to ensure highly specific and sensitive detection in on-field diagnosis.
Sakshi Singh
Read the Original
This page is a summary of: Exploring the Cell Wall and Secretory Proteins of Mycobacterium leprae
as Biomarkers, Protein and Peptide Letters, January 2024, Bentham Science Publishers,
DOI: 10.2174/0109298665267993231026114709.
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