What is it about?
Studies have evaluated models of thiamine deficiency in laboratory rodents. The vast majority use the pyrithiamine antagonist as a deficiency inducer. However, amprolium has potential for use in rodents, being widely used in bovine, ovine and caprine studies.
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Why is it important?
We have shown that amprolium is feasible and very interesting for the study of thiamine deficiency in laboratory rodents, through an unprecedented model of oral administration of the antagonist. Amprolium produces changes typical of the disorder, such as weight loss, hyporexia and behavioral changes. However, unlike ruminants, amprolium did not induce CNS lesions, under the conditions of our model.
Perspectives
This first study in mice opens a wide range of investigations into the effects of amprolium. Amprolium is well known but not used in experimental models. It has the great advantage of having a considerably lower cost compared to the other thiamine antagonists. Other works are underway to better understand their actions, and to strengthen their use as inducer of thiamine deficiency in rodents.
Dr Fabiano Mendes de Cordova
Universidade Federal do Norte do Tocantins
Read the Original
This page is a summary of: Amprolium-induced thiamine deficiency in mice: evaluation of a practical model by oral administration, Acta Veterinaria Brasilica, September 2017, Editora da Universidade Federal Rural do Semi-Arido - EdUFERSA,
DOI: 10.21708/avb.2017.11.0.7101.
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