What is it about?

Toxicity of combined exposures of endosulfan and imidacloprid on zebrafish in terms of oxidative stress and deoxyribonucleic acid (DNA) damage in liver and histological alterations in gills and muscles was investigated.

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Why is it important?

Importance of the present study was to assess the potential sublethal effects of endosulfan and imidacloprid on levels of antioxidant enzymes, MDA, and DNA damage and histopathological alterations in gill and muscle tissues of zebrafish.

Perspectives

Tainted water is responsible for the weak growth, disease outbreak, reproduction efficiency and also for survival and death of fish. To our knowledge, this is the first study to report the combined effects on oxidative stress and histopathology in zebrafish exposed to endosulfan and imidacloprid present in water.The present study revealed that the pesticides stimulated the antioxidant enzyme activities (CAT and SOD) at low concentrations, but high concentrations of pesticides and prolonged exposure duration decreased the activity of both enzymes. Based on the present study, it may be concluded that environmental pollutioncan be evaluated by measuring biochemical responses in organisms against stress.All the negative effects of pesticides must be taken into account while using these agrochemicals for insect-pest control in agricultural fields surrounding freshwater ecosystems. Thus, it is recommended that proper maintenance and measures are necessary in order to keep these water bodies clean and safe.

Dr. Mazhar Iqbal Zafar
Quaid-i-Azam University

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This page is a summary of: Stress response and toxicity studies on zebrafish exposed to endosulfan and imidacloprid present in water, Journal of Water Supply Research and Technology—AQUA, September 2019, IWA Publishing,
DOI: 10.2166/aqua.2019.077.
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