What is it about?
Investigating the potential effects of ABCG2 genetic polymorphisms in mediating the effects of methotrexate on blood pressure and arterial function in patients with rheumatoid arthritis.
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Why is it important?
The studied polymorphisms might be important in selecting patients that are more likely to respond to the effects of methotrexate on blood pressure and arterial function.
Perspectives
Larger, longitudinal studies are warranted to confirm the biological role of the ABCG2 polymorphism in mediating the effects of methotrexate on blood pressure and arterial function.
Arduino Mangoni
Flinders University
Read the Original
This page is a summary of: Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study, Pharmacogenomics and Personalized Medicine, November 2018, Dove Medical Press,
DOI: 10.2147/pgpm.s170557.
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