What is it about?
Combining testing procedures in cancer screening can help reach good predictive values, even when each test alone does not have high sensitivity or/and specificity. This approach is especially helpful when the gold standard tests are invasive procedures, with high risks and/or low compliance on the patients' side. This papers presents a validated combination scheme and strategy, analyzing the predictive values as function of prevalence.
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Why is it important?
Our analysis shows how combining less resource challenging and less invasive tests is worthwhile in usual screening scenarios, with good and reliable predictive values.
Perspectives
This joint project aimed at evaluating the feasibility of a cancer screening program was a fruitful professional experience for me and I do hope our paper will help other teams who face similar dilemmas in choosing the best strategy.
Dr Diana Lungeanu
University of Medicine and Pharmacy Timisoara
Read the Original
This page is a summary of: Diagnosis reliability of combined flexible sigmoidoscopy and fecal-immunochemical test in colorectal neoplasia screening, OncoTargets and Therapy, November 2016, Dove Medical Press,
DOI: 10.2147/ott.s122425.
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