What is it about?
In this study, 68Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic iron oxide nanoparticles were synthesized and assessed in vitro and in vivo as a targeted PET/MR imaging agent for early detection of gastrin-releasing peptide (GRP)-avid breast cancer.
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Why is it important?
Breast cancer (BC) is the most invasive cancer in women and early detection of BC is the most important strategy to treat the disease easily. PET/MR dual-modality imaging can merge the high spatial resolution of MRI with excellent sensitivity and quantitative data analysis of PET for early detection of cancers. So, the design of targeted PET/MR imaging probes for BC can help the accurate diagnosis and Timely treatment of this disease. With this aim, we designed and synthesized a new targeted PET/MR imaging probe to detect gastrin-releasing peptide (GRP)-avid BC.
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This page is a summary of: 68Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation, International Journal of Nanomedicine, April 2019, Dove Medical Press,
DOI: 10.2147/ijn.s195223.
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