What is it about?
Low concentrations of colistin in combination with other antimicrobials could be useful to treat infections due to multidrug resistantbacteria. We demonstrated that sub-inhibitory concentrations of colistin increase the activity of antimicrobials whose mechanisms of resistance are associated with efflux systems and/or decreased permeability.
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Why is it important?
Our findings show that, by altering the permeability of the outer membrane of Gram-negative bacteria, colistin acts synergistically with a broad spectrum of antimicrobials. The mechanism of action involves modification of membrane fluidity as well as the direct partial inhibition of efflux pump function.
Perspectives
I hope this article helps to reduce the number of deaths caused by multi-drug-resistant (MDR) bacteria and development of aternative treatments to treat them. This article also contributes to a better understanding of the mechanism of action of colistin.
Ester Fusté
Universitat de Barcelona
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This page is a summary of: Efficacy of combinations of colistin with other antimicrobials involves membrane fluidity and efflux machinery, Infection and Drug Resistance, July 2019, Dove Medical Press,
DOI: 10.2147/idr.s207844.
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