What is it about?
We performed a genetic analysis of influenza viruses sequences reported in Mexico during 2000-2017 and summarized the main nucleotide and amino acidic variations in the two proteins used as target to drug action: matriz 2 (M2) and neuraminidase (NA) inhibitors. Seven percent of the all serotypes of influenza virus A sequences analyzed in Mexico from 2000 to 2017 have mutations conferring resistance to NA inhibitors.
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Why is it important?
Influenza causes high rates of morbidity and mortality. The failure of antiviral drugs is largely due to the genetic changes in influenza viruses. In this regard, surveillance of anti-influenza drug resistance has great global relevance.
Perspectives
Due the resistance and the limited availability of influenza drugs, it is necessary to increase the epidemiological surveillance, including molecular analysis, which will provide data such as the presence of changes associated with antiviral resistance, which represents an increase in the risk of death in patients with severe infection and higher healthcare costs.
Gerardo Santos-López
Instituto Mexicano del Seguro Social
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This page is a summary of: Antiviral resistance markers in influenza virus sequences in Mexico, 2000–2017, Infection and Drug Resistance, October 2018, Dove Medical Press,
DOI: 10.2147/idr.s153154.
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