What is it about?
In the early hours of hypoxia, the inhibitory phosphorylation of the PDH is not depended on HIF-1a or the increased expression of the PDK1
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Why is it important?
Most of the effects occurring under hypoxic conditions have been attributed to HIF-1a or its downstream targets. Here we show, however that the down regulation of the PDH activity and thereby the TCA cycle as well as the oxidative phosphorylation are within the early hours under hypoxic conditions neither dependent on HIF-1a nor the up-regulation of the PDK1 expression. This adds up to our knowledge about the many diverse effects occurring under hypoxia and shows that there are effects occurring which are not regulated by HIF-1.
Perspectives
I think that the field of hypoxia research is experiencing a little Renaissance since the discovery and functional description of the several HIF isoforms. I believe that there are many more effects such as this one to be found, which will broaden our understanding of the many alterations occurring under hypoxia.
Dr. Andreas D. Zimmer
Read the Original
This page is a summary of: Phosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells, Hypoxia, August 2016, Dove Medical Press,
DOI: 10.2147/hp.s99044.
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