What is it about?
In this retrospective study, we found that the non-thyroidal illness syndrome, or low-T3 syndrome, is associated with disequilibrium of the bone metabolic-related markers in patients with Type II diabetes. This comparative study demonstrated that despite age, gender, bodyweight, hepatic, renal function, thyroid hormone and pancreatic function were significant factors associated with bone metabolism in patients with T2D and Low T3 syndrome, which may increase the risk of osteoporosis.
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Why is it important?
We observed different profiles of patients with or without Low T3 syndrome, which lies in nutritional deficit, low BMI, and deteriorated liver and kidney function, accompanied by a long duration of T2DM. Thus, the dysregulation of thyroid hormones and bone markers may be the superficial manifestation of these populations since DM is related to thyroid hormones. Improving the comprehensive metabolic status in these patients may help adjust their prognosis.
Perspectives
Although simple low T3 syndrome does not require extra thyroxine supplementation according to the current guideline, conditioning the patients' overall nutritional status or metabolic well-being may help adjust their outcome, which needs intensive clinical investigations.
Dr. Song Wen
Shanghai Pudong Hospital
Read the Original
This page is a summary of: Low T3 Syndrome is Associated with Imbalance of Bone Turnover Biomarker in Patients with Type 2 Diabetes, Diabetes Metabolic Syndrome and Obesity, October 2024, Taylor & Francis,
DOI: 10.2147/dmso.s472946.
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